Homology
Homologs of the ADAM33 protein were obtained using the Homologene online database [1]. Listed below are 5 species with have the ADAM33 gene. Protein identity is the amount of amino acids that align between Humans and the organisms, while gene identity is the amount of nucleotides that match between humans and the organism.
Canis lupus familiaris (Dog)
Gene Name: ADAM33 Amino Acids Aligned: 878 Protein accession number: XP_542918.2 Protein Identity: 78.1% Gene Identity: 83.5% Bos taurus (Cow) Gene Name: ADAM33 Amino Acids Aligned: 987 Protein accession number: XP_601929.3 Protein Identity: 75.8% Gene Identity: 81.7% Mus musculus (Mouse) Gene Name: ADAM33 Amino Acids Aligned: 797 Protein accession number: NP_291093.1 Protein Identity: 72.7% Gene Identity: 78.4% |
Gallus Gallus (Red Junglefoul)
Gene Name: ADAM33 Amino Acids Aligned: 777 Protein accession number: XP_420886.2 Protein Identity: 58.7% Gene Identity: 65.9% Rattus norvegicus (Rat) Gene Name: ADAM33 Amino Acids Aligned: 780 Protein accession number: XP_230607.4 Protein Identity: 73.0% Gene Identity: 78.3% |
Related ADAM Proteins
ADAM's are a relatively large family of proteins. An analysis from a table from Tree Fam, shows a large amount of ADAM proteins found in multiple organisms. Alignment and a clean tree can be seen by following the link. [2] Shown below is a blast alignment of the ADAM33 protein. [3]
Analysis
The ADAM family of proteins is very large and found many Eukaryotic animals. They are not found in plant, archaeal, bacterial or viral proteins. [4] Specific homologs of ADAM33 are found in cows, dogs, mice, red junglefouls, and rats. A similar structure in lung structure and immune systems would leave cows, dogs, mice, and rats as viable model organisms for research.